Dayhoff-170M-GRS-SS-26000

microsoft/Dayhoff-170M-GRS-SS-26000

Publisher微软（Microsoft）Verified

Download access requirementsMirror available

Dayhoff 是一个蛋白质序列数据与生成式语言模型的整合资源库。该模型汇集了33.4亿条蛋白质序列，涵盖17亿个宏基因组和自然蛋白质序列簇（GigaRef）、4600万条结构衍生的合成序列（BackboneRef）以及1600万条多序列比对（OpenProteinSet）。## 主要能力通过进化或结构上下文条件来搭建结构基序的支架输入：单序列或展开的多序列比对（MSA）

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Model details

模型介绍

中文整理

# Dayhoff 模型卡片

## 用途

Dayhoff 是一个蛋白质序列数据与生成式语言模型的整合资源库。该模型汇集了33.4亿条蛋白质序列，涵盖17亿个宏基因组和自然蛋白质序列簇（GigaRef）、4600万条结构衍生的合成序列（BackboneRef）以及1600万条多序列比对（OpenProteinSet）。## 主要能力

零样本预测突变对适应度的影响
通过进化或结构上下文条件来搭建结构基序的支架
在指定家族内引导生成新型蛋白质
无条件设计蛋白质序列
在序列空间中为结构基序设计支架
同源物条件生成

## 输入输出

输入：单序列或展开的多序列比对（MSA）
输出：蛋白质序列或同源蛋白质序列集

运行要求

PyTorch 2.7.1
CUDA 12.8及以上
依赖库：mamba-ssm、causal-conv1d、flash-attn
1.7亿参数模型：8块NVIDIA A100或8块NVIDIA H100 GPU
30亿参数模型：176块NVIDIA H100 GPU

基本用法

推荐使用uv创建干净环境并安装PyTorch 2.7.1，然后安装mamba-ssm、flash-attn、causal-conv1d及其依赖。通过HuggingFace接口调用模型。

限制

仅限生成蛋白质序列或同源蛋白质序列，不得用于自然语言或其他生物序列（如DNA序列）
不保证所有生成的序列都真实可信
难以生成与任何自然序列无同源性的高质量序列

License

MIT许可证

优先采用原作者提供的中文模型卡片；仅有英文说明时由闲社AI翻译整理。重要参数、许可证和商用范围请以原文为准。

你将获得什么

完整仓库方式包含该固定版本中的权重、配置、分词器及说明文件；指定版本方式只下载所选文件或整组分片。多模态模型的投影文件、配置等依赖，请按作者说明配齐。

完整仓库可能包含多个权重格式，因此需要的磁盘空间可能大于单一格式的模型大小。下载文件不等于完成模型部署。

使用前须知

运行环境

运行模型需要的设备、工具与依赖，以原作者说明为准。

授权范围

是否允许商用、修改和分发，请查看模型许可证。

闲社提供资料与镜像下载方法，不代表已运行模型或完成安全审计。下载的代码应先检查，再执行。

Problem with the information or download?

Pinned version · Multiple download options

Dayhoff-170M-GRS-SS-26000 model download

Download the full repository or choose a version or file.

Download tools · More than GGUF

Use the Hugging Face download tool to obtain microsoft/Dayhoff-170M-GRS-SS-26000. Download Safetensors, GGUF, ONNX, configuration and other repository files. Downloading does not mean the tool can run this model.

Pinned-version file information is being completed. Existing downloads remain available, or load the file manifest below.

Choose a mirror or official source, your operating system and download scope below, then copy the command. Install the download tool first if needed.

Pinned version: b2653be56a0082a8fc7fc5be2450debfcb4a3e23. Downloads files only; does not start the model.

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Choose what to download

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Quantization / file

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Choose your operating system

For command-line downloads, follow these steps to get the full repository or selected files. Direct file links do not need these steps.

Open a terminal window

Create and open a folder for the model. In the folder's address bar, enter powershell and press Enter.

If Python is not installed, get it from the official Python website. In the terminal, enter python --version; continue when a version number appears.

First time? Install the download tool

Copy this command, paste it into the terminal, press Enter and wait for installation to finish.

python -m pip install --upgrade huggingface_hub

Already installed? Continue to step 3.

Run the download command

Select the button below, paste into the same terminal and press Enter. The tool downloads all files included in the current command.

Copying does not start a download. Paste and run the command on your device.

Where are the downloaded files?

Open the folder you chose. Look for the models folder. When progress stops and the terminal returns to its prompt without errors, check that all files are present. 'Copied' does not mean 'downloaded'.

No response or an error?

python not found: Install Python and reopen the terminal. On Windows, follow the installer's instructions to enable command-line access.

hf not found: Confirm that step 2 succeeded, then reopen the terminal. If needed, add Python's Scripts folder to your user PATH. Do not repeatedly download scripts.

Network interrupted: Stay in the same folder and run the same command again. The tool checks existing files.

Permission or disk error: Choose a writable folder with enough free space. Do not disable system security protection.

View the full download command

$env:HF_ENDPOINT = "https://huggingface.co"
$env:HF_HUB_DISABLE_IMPLICIT_TOKEN = "1"
$env:HF_HUB_DISABLE_XET = "1"
hf download "microsoft/Dayhoff-170M-GRS-SS-26000" --revision "b2653be56a0082a8fc7fc5be2450debfcb4a3e23" --local-dir "./models/microsoft--Dayhoff-170M-GRS-SS-26000"

Files transfer directly from the source you choose, not through Xianshe servers.

The version is pinned. Repeating the same command checks existing files. Change the source manually if it is slow or unavailable.

Public models do not require submitting keys to Xianshe. Restricted models still require the author's authorization. On Linux / macOS, use python3 instead of python when appropriate.